產品介紹

ADC Cytotoxin;ADC Cytotoxin;描述：Mitomycin C (Ametycine) 是一種 DNA 交聯劑 (DNA cross-linking agent)，誘導 DNA 損傷。Mitomycin C 是一種抗腫瘤化合物和抗生素，可有效的抑制 DNA 合成 (DNA synthesis)。Mitomycin C 是一種 ADC 毒性分子 (ADC Cytotoxin)，可以誘導凋亡 (Apoptosis) 作用。;InformationMitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.In?vitroMitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. [1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. [2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity.In?vivoAs the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth.Cell?Datacell?lines：Concentrations：Incubation?Time：Powder Purity:≥97%