產(chǎn)品介紹

選擇性，細(xì)胞滲透性p300 / CBP HAT抑制劑;Selective, cell permeable p300/CBP HAT inhibitor;存放在干燥的條件下。該產(chǎn)品最多可存儲(chǔ)12個(gè)月。一般描述組蛋白乙酰轉(zhuǎn)移酶抑制劑II(HAT Inhibitor II, compound 2c) 是一種有效的、選擇性的且可透過細(xì)胞的 p300 histone acetyltransferase (HAT) 的抑制劑，其IC50值為5 μM。Histone Acetyltransferase Inhibitor II 在哺乳動(dòng)物細(xì)胞中顯示出抗乙酰酶活性。組蛋白乙酰轉(zhuǎn)移酶抑制劑II(compound 2c) 是一種有效的，選擇性的，細(xì)胞滲透的 p300 抑制劑，IC50 值為 5 μM，可用于癌癥研究;Store under desiccating conditions. The product can be stored for up to 12 months.DescriptionA cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 μM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 μM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤40 μM) and induce chromatin condensation in HeLa cells.A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 μM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 μM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤ 40 μM) and induce chromatin condensation in HeLa cells.