貨號	規(guī)格	價格	上海	北京	武漢	南京
S88761-2mg	99.9%	￥382.50 S88761-2mg ￥382.50 現(xiàn)貨	5 5	-	-	-
S88761-5mg	99.9%	￥595.00 S88761-5mg ￥595.00 現(xiàn)貨	6 6	-	-	-
S88761-10mg	99.9%	￥935.00 S88761-10mg ￥935.00 現(xiàn)貨	8 8	-	-	-
S88761-25mg	99.9%	￥1480.00 S88761-25mg ￥1480.00 現(xiàn)貨	6 6	-	-	-
S88761-50mg	≥98%	￥2350.00 S88761-50mg ￥2350.00 2-3天	0 貨期：2-3天	-	-	-
S88761-100mg	≥98%	￥4200.00 S88761-100mg ￥4200.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.

產(chǎn)品描述：

NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.

靶點：

IC50: 1 μM (PI5P4Kγ);PI3K

體外研究：

NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks

參考文獻：

1. Clarke JH, et al. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466(2):359-67.

溶解性：

Soluble in DMSO

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.595 ml	12.973 ml	25.946 ml
5 mM	0.519 ml	2.595 ml	5.189 ml
10 mM	0.259 ml	1.297 ml	2.595 ml
50 mM	0.052 ml	0.259 ml	0.519 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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