貨號	規格	價格	上海	北京	武漢	南京
S88647-1mg	99.2%	￥140.00 S88647-1mg ￥140.00 現貨	3 3	-	-	-
S88647-5mg	99.2%	￥330.00 S88647-5mg ￥330.00 現貨	4 4	-	-	-
S88647-10mg	99.2%	￥440.00 S88647-10mg ￥440.00 現貨	5 5	-	-	-
S88647-25mg	99.2%	￥590.00 S88647-25mg ￥590.00 現貨	4 4	-	-	-
S88647-50mg	≥98%	￥790.00 S88647-50mg ￥790.00 2-3天	0 貨期：2-3天	-	-	-
S88647-100mg	≥98%	￥1350.00 S88647-100mg ￥1350.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM

產品描述：

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM

靶點：

IC50: 440 nM (MMP-9 zymogen);MMP

體外研究：

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species

體內研究：

The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM), respectively, whereas the 30-mg/kg dose achieves 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in brain. JNJ0966 is preferentially partitioned in brain, with brain/plasma ratios of 6.2 for the 10-mg/kg dose and 4.7 for the 30-mg/kg dose

參考文獻：

1. Scannevin RH, et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) thatallosterically inhibits zymogen activation. J Biol Chem. 2017 Oct 27;292(43):17963-17974.

溶解性：

Soluble in DMSO

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.774 ml	13.872 ml	27.743 ml
5 mM	0.555 ml	2.774 ml	5.549 ml
10 mM	0.277 ml	1.387 ml	2.774 ml
50 mM	0.055 ml	0.277 ml	0.555 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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