貨號	規格	價格	上海	北京	武漢	南京
S88466-5mg	98.0%	￥180.00 S88466-5mg ￥180.00 現貨	5 5	-	-	-
S88466-10mg	98.0%	￥340.00 S88466-10mg ￥340.00 現貨	5 5	-	-	-
S88466-25mg	98.0%	￥730.00 S88466-25mg ￥730.00 現貨	5 5	-	-	-
S88466-50mg	≥98%	￥1370.00 S88466-50mg ￥1370.00 2-3天	0 貨期：2-3天	-	-	-
S88466-100mg	≥98%	￥2330.00 S88466-100mg ￥2330.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential utility in MAPK pathway dysregulated tumors.

產品描述：

KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential utility in MAPK pathway dysregulated tumors.

靶點：

ERK1;ERK2;ERK

體內研究：

In cell-line derived xenograft studies, KO-947 profoundly suppresses ERK signaling for up to five days after a single dose and induces regressions in RAS- and RAF-mutant melanoma, NSCLC and pancreatic cancer models on administration schedules ranging from daily to weekly. Intermittent dosing enables comparable antitumor activity at reduced dose-intensity

參考文獻：

1. Burrows F, et al. KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, D

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.814 ml	14.069 ml	28.138 ml
5 mM	0.563 ml	2.814 ml	5.628 ml
10 mM	0.281 ml	1.407 ml	2.814 ml
50 mM	0.056 ml	0.281 ml	0.563 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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