| 產品描述： | SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction. |
| 靶點： |
Wnt/beta-catenin |
| 細胞實驗： |
The HEK293 reporter and control cell lines were established. The HEK293 reporter cells were inoculated into 384-well plates at 10 000 cells per well and grown for 24 h. Next, each compound in the chemical library (～270 000) was added to at a final concentration of 20 μM. After 15 h, the plates were assayed for firefly luciferase activity.(Only for Reference) |
| 參考文獻： |
1. Lu F, Sun X, Xu X, et al. SILAC-based proteomic profiling of the suppression of TGF-β1-induced lung fibroblast-to-myofibroblast differentiation by trehalose[J]. Toxicology and Applied Pharmacology. 2020, 391: 114916. 2. Lu F, Sun X, Xu X, et al. SILAC-based proteomic profiling of the suppression of TGF-β1-induced lung fibroblast-to-myofibroblast differentiation by trehalose[J]. Toxicology and Applied Pharmacology. 2020: 114916. 3. Gwak J, et al. Cell Res. 2012, 22(1):237-47. |
| 溶解性： |
Soluble in DMSO、Ethanol |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.493 ml |
17.465 ml |
34.93 ml |
| 5 mM |
0.699 ml |
3.493 ml |
6.986 ml |
| 10 mM |
0.349 ml |
1.747 ml |
3.493 ml |
| 50 mM |
0.07 ml |
0.349 ml |
0.699 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京