貨號	規格	價格	上海	北京	武漢	南京
S88002-5mg	99.9%	￥330.00 S88002-5mg ￥330.00 現貨	6 6	-	-	-
S88002-10mg	99.9%	￥540.00 S88002-10mg ￥540.00 現貨	6 6	-	-	-
S88002-25mg	99.9%	￥650.00 S88002-25mg ￥650.00 現貨	6 6	-	-	-
S88002-100mg	≥98%	￥1900.00 S88002-100mg ￥1900.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively

產品描述：

Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively

靶點：

B-Raf:1 nM (Ki);B-RafV600E:1 nM (Ki);c-Raf:0.3 nM (Ki);Raf

體外研究：

B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.

參考文獻：

1. Wang X, et al. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.812 ml	9.06 ml	18.121 ml
5 mM	0.362 ml	1.812 ml	3.624 ml
10 mM	0.181 ml	0.906 ml	1.812 ml
50 mM	0.036 ml	0.181 ml	0.362 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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B-Raf inhibitor 1 (dihydrochloride)

1-N-(4-Chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine dihydrochloride