| 產(chǎn)品描述： | Aftin-4 is an Amyloid-β42 (Aβ42) inducer |
| 靶點(diǎn)： |
Amyloid-β;BetaAmyloid;?Gamma-secretase |
| 體外研究： |
Aftin-4 selectively and potently increases Aβ1-42 in N2a cells, primary neurons, and brain lysates, with an EC50 value around 30 μM |
| 體內(nèi)研究： |
Aftin-4 increases Aβ1-42?levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ1-40?or Aβ1-42?is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ1-42?content, up to +216% at the highest dose tested |
| 參考文獻(xiàn)： |
1. Meunier J, et al. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative. J Alzheimers Dis. 2015;44(2):507-24. |
| 溶解性： |
Soluble in DMSO |
| 保存條件： |
-20°C |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.714 ml |
13.569 ml |
27.139 ml |
| 5 mM |
0.543 ml |
2.714 ml |
5.428 ml |
| 10 mM |
0.271 ml |
1.357 ml |
2.714 ml |
| 50 mM |
0.054 ml |
0.271 ml |
0.543 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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