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APD597

    
98%

源葉(MedMol)
S87719 一鍵復制產品信息
897732-93-3
C21H29N5O6S
479.55
JNJ-38431055
貨號 規格 價格 上海 北京 武漢 南京 購買數量
S87719-5mg 98% ¥640.00 6 - - -
S87719-10mg 98% ¥1040.00 7 - - -
S87719-25mg 98% ¥2080.00 6 - - -
S87719-100mg 98% ¥5600.00 貨期:2-3天 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. IC50 value: 46 nM (EC50) Target: hGPR119 The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described. APD597 was selected for preclinical development based on a good balance between agonist potency, intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential.

產品描述: APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. IC50 value: 46 nM (EC50) Target: hGPR119 The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described. APD597 was selected for preclinical development based on a good balance between agonist potency, intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential.
靶點: GPR119;GPR
參考文獻: 1. Buzard DJ, et al. Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-4335. 2. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Sci Rep. 2017 Jun 28;7(1):4351. 3. Semple G, et al. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improvedprofile. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-1755.
溶解性: Soluble  in  DMSO
保存條件: -20°C
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.085 ml 10.426 ml 20.853 ml
5 mM 0.417 ml 2.085 ml 4.171 ml
10 mM 0.209 ml 1.043 ml 2.085 ml
50 mM 0.042 ml 0.209 ml 0.417 ml
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參考文獻

質檢證書(COA)

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批號:JS298415 貨號:S20001-25g
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摩爾濃度計算器

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