| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S86545-1mg |
99.8% | ￥98.00 | 9 | - | - | - |
|
S86545-5mg |
99.8% | ￥380.00 | 5 | - | - | - |
|
S86545-10mg |
99.8% | ￥620.00 | 6 | - | - | - |
|
S86545-50mg |
≥98% | ￥2100.00 | 貨期：2-3天 | - | - | - |
|
S86545-100mg |
≥98% | ￥3950.00 | 貨期：2-3天 | - | - | - |
|
DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.
| 產品描述： | DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | Microtubule/Tubulin;ADC Cytotoxin;MicrotubuleAssociated | ||||||||||||||||||||
| 體外研究： | DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death | ||||||||||||||||||||
| 參考文獻： | 1. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
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營業執照(三證合一)
北京