貨號	規格	價格	上海	北京	武漢	南京
S86176-5mg	99.9%	￥476.00 S86176-5mg ￥476.00 現貨	9 9	-	-	-
S86176-10mg	99.9%	￥816.00 S86176-10mg ￥816.00 現貨	9 9	-	-	-
S86176-50mg	99.9%	￥2700.00 S86176-50mg ￥2700.00 現貨	2 2	-	-	-
S86176-100mg	≥99%	￥4300.00 S86176-100mg ￥4300.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

RSV-604 is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM)

產品描述：

RSV-604 is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM)

靶點：

RSV

體外研究：

RSV-604 increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM) and inhibits RSV replication in human airway epithelial (HAE) cell monolayers following mucosal inoculation

體內研究：

RSV604 resistance mutations in the N protein. RSV604 engaged in two different MoAs in HeLa cells, inhibiting both RSV RNA synthesis and the infectivity of released virus. RSV604 did not inhibit viral RNA synthesis in the RSV subgenomic replicon cells or in the cell-free RNP assay, suggesting that it might act prior to viral replication complex formation. RSV604 did not alter N protein localization in the infected cells

參考文獻：

1. RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication[J]. Antimicrobial Agents and Chemotherapy, 2007, 51(9):3346-3353. 2. Challa S, Scott AD, Yuzhakov O,et al.Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604[J].Antimicrob Agents Chemother. 2015 Feb

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.575 ml	12.874 ml	25.747 ml
5 mM	0.515 ml	2.575 ml	5.149 ml
10 mM	0.257 ml	1.287 ml	2.575 ml
50 mM	0.051 ml	0.257 ml	0.515 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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