|
產品描述： ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells |
|
靶點：
IC50: 0.69 μM (KV7.2/7.3), 14.3 μM (KV7.3/7.5);PotassiumChannel |
體外研究：
ICA-069673（100 nM-30 μM）劑量依賴性地抑制豚鼠 DSM 分離試紙中的自發相位收縮、藥理學誘導的收縮和 10 Hz EFS 誘導的神經誘發收縮。< br/> ICA-069673（3 μM，10 μM）抑制豚鼠 DSM 分離條中 20 mM KCl 誘導的 DSM 強直收縮 |
參考文獻：
1. Provence A, et al. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep;354(3):290-301. |
|
溶解性：
soluble in DMSO |
|
保存條件：
-20℃ |
配置溶液濃度參考：
|
1mg |
5mg |
10mg |
| 1 mM |
3.709 ml |
18.544 ml |
37.087 ml |
| 5 mM |
0.742 ml |
3.709 ml |
7.417 ml |
| 10 mM |
0.371 ml |
1.854 ml |
3.709 ml |
| 50 mM |
0.074 ml |
0.371 ml |
0.742 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京