品牌	貨號	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S85811-5mg	99%	￥780.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S85811-10mg	99%	￥1100.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S85811-50mg	99%	￥3900.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S85811-100mg	99%	￥6800.00元	預(yù)計(jì)交期：2-3天	-	-	-

產(chǎn)品介紹

Etifoxine hydrochloride, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine hydrochloride reveals anxiolytic and anticonvulsant properties in rodents

產(chǎn)品描述： Etifoxine hydrochloride, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine hydrochloride reveals anxiolytic and anticonvulsant properties in rodents

靶點(diǎn)： GABA Receptor;GABAReceptor

體內(nèi)研究：
Etifoxine competitively inhibits [35S]TBPS binding with micromolar potency in rat brain. Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice Animal Model: Six-week old BALB/cByJ and C57BL/6J mice (20-25 g). Dosage: 3.125-50 mg/kg. Administration: Intraperitoneal inhection. Result: Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice.BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min.

參考文獻(xiàn)：
1. Marc Verleye, et al. Effects of etifoxine on ligand binding to GABA(A) receptors in rodents. Neurosci Res. 2002 Oct;44(2):167-72. 2. Alain Hamon, et al. The modulatory effects of the anxiolytic etifoxine on GABA(A) receptors are mediated by the beta subunit. Neuropharmacology. 2003 Sep;45(3):293-303. 3. Marc Verleye, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21(6):457-70.

溶解性： Soluble in DMSO、H2O

保存條件： -20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.965 ml	14.826 ml	29.652 ml
5 mM	0.593 ml	2.965 ml	5.93 ml
10 mM	0.297 ml	1.483 ml	2.965 ml
50 mM	0.059 ml	0.297 ml	0.593 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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Etifoxine Hydrochloride 99%

Etifoxine Hydrochloride