貨號	規格	價格	上海	北京	武漢	南京	購買數量
S85560-5mg	≥98%	￥3500.00 S85560-5mg ￥3500.00 2-3天	0 貨期：2-3天	-	-	-
S85560-10mg	≥98%	￥6000.00 S85560-10mg ￥6000.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively.

產品描述：

DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively.

靶點：

DNMT1:0.91 μM (Kd);DNMT1:1.7 μM (IC50);DNAMethyltransferase

體外研究：

DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively. DC_517 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC_517 (0, 0.75, 1.5, and 3 μM) also dose-dependently induces apoptotic cell death in HCT116 cells

參考文獻：

1. Chen S, et al. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57(21):9028-9041.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.978 ml	9.888 ml	19.777 ml
5 mM	0.396 ml	1.978 ml	3.955 ml
10 mM	0.198 ml	0.989 ml	1.978 ml
50 mM	0.04 ml	0.198 ml	0.396 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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