貨號	規格	價格	上海	北京	武漢	南京
S85422-1mg	≥98%	￥190.00 S85422-1mg ￥190.00 2-3天	0 貨期：2-3天	-	-	-
S85422-5mg	99.9%	￥476.00 S85422-5mg ￥476.00 現貨	3 3	-	-	-
S85422-10mg	99.9%	￥714.00 S85422-10mg ￥714.00 現貨	9 9	-	-	-
S85422-50mg	99.9%	￥2700.00 S85422-50mg ￥2700.00 現貨	6 6	-	-	-
S85422-100mg	99.9%	￥3900.00 S85422-100mg ￥3900.00 現貨	5 5	-	-	-

產品介紹

Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation

產品描述：

靶點：

ERK1;ERK2;PiezoChannel

體外研究：

Yoda1 (0-6 μM, 5 min) induces the activation of both Akt and ERK1/2, which is not dependent on Piezo1. Yoda1 (1.5 μM, 5 min) inhibits Rac1 activation. Western Blot Analysis Cell Line: human coronary artery endothelial cells (HCAECs)[2], A431 cells Concentration: 0, 1.5, 3.0, and 6.0?μM Incubation Time: 5 min Result: Induced the activation of both Akt and ERK1/2, and increased the phosphorylation levels of both Akt and ERK1/2 in a dose-dependent manner. Inhibited EGF-induced increase in the amount of Rac1-GTP, and inhibited Rac1 activation

參考文獻：

1. Syeda R, et al. Chemical activation of the mechanotransduction channel Piezo1. Elife. 2015 May 22;4. 2. Dela Paz NG, et al. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun. 2018 Feb 26;497(1):220-225. 3. Kuriyama M, et al. Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells. Sci Rep. 2022 Apr 15;12(1):6322.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.815 ml	14.074 ml	28.148 ml
5 mM	0.563 ml	2.815 ml	5.63 ml
10 mM	0.281 ml	1.407 ml	2.815 ml
50 mM	0.056 ml	0.281 ml	0.563 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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