貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S84314-5mg	≥99%	￥2800.00 S84314-5mg ￥2800.00 2-3天	0 貨期：2-3天	-	-	-
S84314-10mg	≥99%	￥4800.00 S84314-10mg ￥4800.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibits significant in vitro anti-HBV activity (EC50: 0.08 μM in HepG2.2.15 cells).

產(chǎn)品描述：

Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibits significant in vitro anti-HBV activity (EC50: 0.08 μM in HepG2.2.15 cells).

靶點：

HBV

體外研究：

Helioxanthin derivative 5-4-2 had potent anti-HBV activities in HepG2.2.15 cells, with the EC50s of 1 and 0.08 microM, respectively. The lamivudine-resistant HBV, L526M/M550V double mutant strain, was also sensitive to helioxanthin and 5-4-2. This class of compounds not only inhibited HBV DNA but also decreased HBV mRNA and HBV protein expression. The EC50 of HBV DNA inhibition was consistent with the EC50 of HBV 3.5 Kb transcript inhibition, which was 1 and 0.09 microM for helioxanthin and 5-4-2 respectively.

參考文獻(xiàn)：

1. Li Y, et al. Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother. 2005;16(3):193-201. 2. Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.879 ml	14.396 ml	28.792 ml
5 mM	0.576 ml	2.879 ml	5.758 ml
10 mM	0.288 ml	1.44 ml	2.879 ml
50 mM	0.058 ml	0.288 ml	0.576 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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