貨號	規格	價格	上海	北京	武漢	南京
S84122-1mg	99.9%	￥80.00 S84122-1mg ￥80.00 現貨	6 6	-	-	-
S84122-2mg	99.9%	￥120.00 S84122-2mg ￥120.00 現貨	7 7	-	-	-
S84122-5mg	99.9%	￥180.00 S84122-5mg ￥180.00 現貨	7 7	-	-	-
S84122-10mg	99.9%	￥260.00 S84122-10mg ￥260.00 現貨	7 7	-	-	-
S84122-25mg	99.9%	￥610.00 S84122-25mg ￥610.00 現貨	5 5	-	-	-
S84122-50mg	99.9%	￥770.00 S84122-50mg ￥770.00 現貨	5 5	-	-	-
S84122-100mg	99.9%	￥1340.00 S84122-100mg ￥1340.00 現貨	5 5	-	-	-

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產品介紹

Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.

產品描述：

Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.

靶點：

GABA receptor;GABAReceptor

體內研究：

AWD 131-138 did not produce midazolam-like responding or alter response rates at cumulative doses up to 18.0 mg/kg i.m. (plasma levels over 2100 ng/ml). When AWD 131-138 (10-100 microg/kg/injection) was studied by substitution, responding declined to vehicle substitution levels within three sessions. At the dose of 100 microg/kg i.v. AWD 131-138, sufficient drug was self-administered during the first session (about 3.5 mg/kg) to produce plasma levels above 1000 ng/ml, yet responding over the next two sessions dropped to vehicle levels [2]. Prolonged oral administration with twice-daily dosing of ELB 138 with either 5 or 40 mg/kg over a 5-week period was not associated with loss of anticonvulsant efficacy in the PTZ dog model

參考文獻：

1. Sigel E, et al. The antiepileptic drug AWD 131-138 stimulates different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site. Neurosci Lett. 1998 Apr 3;245(2):85-8. 2. Yasar S, et al. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur J Pharmacol. 2003 Apr 4;465(3):257-65. 3. Loscher W, et al. Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. Epilepsia. 2004 Oct;45(10):1228-39.

溶解性：

DMSO : 12.5 mg/mL (44.69 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.575 ml	17.875 ml	35.75 ml
5 mM	0.715 ml	3.575 ml	7.15 ml
10 mM	0.357 ml	1.787 ml	3.575 ml
50 mM	0.071 ml	0.357 ml	0.715 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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AWD-131-138

1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one