貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫存（上海）	北京	武漢	南京	購買數(shù)量
S83973-5mg	99%	￥1950.00 S83973-5mg ￥1950.00 2-3天	0 貨期：2-3天	-	-	-
S83973-10mg	99%	￥2700.00 S83973-10mg ￥2700.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo.

產(chǎn)品描述：

NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo.

靶點(diǎn)：

Neurokinin receptor;Neurokininreceptor

體內(nèi)研究：

Using the hindfoot thumping model in gerbils, NKP608 exhibited a potent NK-1 antagonistic activity following oral administration (ID50: 0.23 mg/kg, 2 h pretreatment), supporting a central activity of NKP608.

參考文獻(xiàn)：

1. Gentsch C, Cutler M, Vassout A, et al. Anxiolytic effect of NKP608, a NK1-receptor antagonist, in the social investigation test in gerbils. Behav Brain Res. 2002 Jul 18;133(2):363-8. 2. Rupniak NM, Carlson EJ, Shepheard S, et al. Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608. Neuropharmacology. 2003 Aug;45(2):231-41. 3. El-Hashim AZ, Wyss D, Lewis C. Effect of a novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airway obstruction. Pulm Pharmacol Ther. 2004;17(1):11-8. 4. Vendruscolo LF, Takahashi RN, Brüske GR, Ramos A. Evaluation of the anxiolytic-like effect of NKP608, a NK1-receptor antagonist, in two rat strains that differ in anxiety-related behaviors. Psychopharmacology (Berl). 2003 Nov;170(3):287-93.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.613 ml	8.065 ml	16.13 ml
5 mM	0.323 ml	1.613 ml	3.226 ml
10 mM	0.161 ml	0.806 ml	1.613 ml
50 mM	0.032 ml	0.161 ml	0.323 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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NKP608