貨號	規格	價格	上海	北京	武漢	南京	購買數量
S83777-1mg	≥98%	￥3000.00 S83777-1mg ￥3000.00 2-3天	0 貨期：2-3天	-	-	-
S83777-5mg	≥98%	￥9800.00 S83777-5mg ￥9800.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor

產品描述：

TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor

靶點：

TACE (ADAM17), MMP;MMP

體外研究：

TAPI-1 (1 μM for 30 min) increases cell viability in LPS-treated HK-2 cells. TAPI-1 attenuates oxidative stress and inflammatory cytokines LPS treatment significantly induces renal IL-6 and TNFα mRNA expression, while these changes is attenuated with TAPI-1 pretreatment in LPS-treated HK-2 cells. Cell Viability Assay Cell Line: LPS-treated HK-2 cells Concentration: 1 μM Incubation Time: 30 minutes (pre-treated) Result: Increased cell viability.

參考文獻：

1. Bae EH, et al. Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells. Korean J Physiol Pharmacol. 2018 Mar;22(2):135-143. 2. Moss ML, et al. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators Inflamm. 2017;2017:9673537.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.002 ml	10.008 ml	20.016 ml
5 mM	0.4 ml	2.002 ml	4.003 ml
10 mM	0.2 ml	1.001 ml	2.002 ml
50 mM	0.04 ml	0.2 ml	0.4 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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分子摩爾量

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