品牌	貨號	產品規格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S83669-2mg	99%	￥200.00元	5	-	-	-
源葉(MedMol)	S83669-5mg	99%	￥260.00元	5	-	-	-
源葉(MedMol)	S83669-10mg	99%	￥300.00元	4	-	-	-
源葉(MedMol)	S83669-50mg	99%	￥890.00元	7	-	-	-
源葉(MedMol)	S83669-100mg	99%	￥1600.00元	6	-	-	-

產品介紹

NIBR189 是 Epstein-Barr virus-induced gene 2 (EBI2, GPR183) receptor 的有效拮抗劑，其結合的IC50值為16 nM，其功能的IC50值為11 nM

產品描述： NIBR189 是 Epstein-Barr virus-induced gene 2 (EBI2, GPR183) receptor 的有效拮抗劑，其結合的IC50值為16 nM，其功能的IC50值為11 nM

靶點： EBI2 (function)(Cell-free assay):11 nM; EBI2 (binding)(Cell-free assay):16 nM;EBI2/GPR183

體外研究：
NIBR189, the EBI2 antagonist, blocks the migration of U937 cells expressing functional EBI2 levels with an IC50 of 0.3 nM

體內研究：
NIBR189 is a potent and selective EBI2 antagonist with pharmacokinetic properties which should allow use for in vitro and in vivo experiments

細胞實驗： Cell lines: U937 cells Concentrations: 20 nM Incubation Time: 3 h Method: Prior to the migration assay, U937 cells were kept overnight in lipid-depleted media. Chemotaxis was performed using HTS Transwell-96 plates with 5.0 μm pore polycarbonate membranes. In brief, lower chambers were filled with 240 μL of compound solution in media in which the FCS was substituted with 1% BSA, and after insertion of the filters, 0.75×105 cells in 75 μL media were added to the upper chamber. After 3 h at 37℃, cells in the lower chamber were analyzed by flow cytometry.

動物實驗： Animal Models: C57BL/6 male mice Dosages: 1 mg/kg (i.v.); 3 mg/kg (p.o.) Administration: i.v., p.o.

參考文獻：
1. Francois Gessier, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57(8):3358-68.

溶解性： Soluble in DMSO、Ethanol

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.329 ml	11.647 ml	23.293 ml
5 mM	0.466 ml	2.329 ml	4.659 ml
10 mM	0.233 ml	1.165 ml	2.329 ml
50 mM	0.047 ml	0.233 ml	0.466 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

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