貨號	規格	價格	上海	北京	武漢	南京
S83523-1mg	≥98%	￥850.00 S83523-1mg ￥850.00 2-3天	0 貨期：2-3天	-	-	-
S83523-5mg	≥98%	￥2600.00 S83523-5mg ￥2600.00 2-3天	0 貨期：2-3天	-	-	-
S83523-10mg	≥98%	￥4000.00 S83523-10mg ￥4000.00 2-3天	0 貨期：2-3天	-	-	-
S83523-25mg	≥98%	￥8600.00 S83523-25mg ￥8600.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Oxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM.

產品描述：

Oxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM.

靶點：

HDAC:15.7 nM (IC50);HDAC

體內研究：

Injection of oxamflatin, six times at the dose of 20 mg/kg, exhibits a significant increase in the days of survival (38% of ILS). The ILS of the mice treated with oxamflatin at the dose of 50 mg/kg is calculated to be more than 67% and one mouse survived over 60 days after tumor inoculation. No subsidiary effect, such as body weight loss, is observed at least up to this dose

參考文獻：

1. Kim YB, et al. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene. 1999 Apr 15;18(15):2461-70. 2. Wang YL, et al. HDAC Inhibitor Oxamflatin Induces Morphological Changes and has Strong Cytostatic Effects in Ovarian Cancer Cell Lines. Curr Mol Med. 2016;16(3):232-42. 3. Faghihloo E, et al. The effect of oxamflatin on the E-cadherin expression in gastric cancer cell line. Cancer Gene Ther. 2016 Nov;23(11):396-399.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.921 ml	14.604 ml	29.208 ml
5 mM	0.584 ml	2.921 ml	5.842 ml
10 mM	0.292 ml	1.46 ml	2.921 ml
50 mM	0.058 ml	0.292 ml	0.584 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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OXAMFLATIN