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KN-92 (hydrochloride)

    
99%

KN-92 (hydrochloride)

源葉(MedMol)
S83292 一鍵復(fù)制產(chǎn)品信息
1431698-47-3
C24H26Cl2N2O3S
493.4458
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數(shù)量
S83292-1mg 99% ¥320.00 >10 - - -
S83292-5mg 99% ¥1070.00 7 - - -
S83292-10mg 99% ¥1820.00 6 - - -
S83292-25mg 99% ¥2970.00 6 - - -
S83292-50mg 99% ¥4560.00 5 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

KN-92 hydrochloride is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 hydrochloride is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93

產(chǎn)品描述: KN-92 hydrochloride is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 hydrochloride is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93
靶點: CaMK
體外研究: KN-93 (5-50μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth. The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21. Cell Viability Assay Cell Line: Human hepatic stellate cells (LX-2) Concentration: 5-50 μM Incubation Time: 24 hours Result: Ineffective in blocking cell growth.
參考文獻: 1. Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070. 2. An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448.
溶解性: Soluble  in  DMSO
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.027 ml 10.133 ml 20.266 ml
5 mM 0.405 ml 2.027 ml 4.053 ml
10 mM 0.203 ml 1.013 ml 2.027 ml
50 mM 0.041 ml 0.203 ml 0.405 ml
注意: 部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。

參考文獻

質(zhì)檢證書(COA)

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批號:JS298415 貨號:S20001-25g
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摩爾濃度計算器

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