貨號	規(guī)格	價格	上海	北京	武漢	南京
S83222-5mg	98.4%	￥150.00 S83222-5mg ￥150.00 現(xiàn)貨	805 >10	-	-	-
S83222-10mg	98.4%	￥245.00 S83222-10mg ￥245.00 現(xiàn)貨	409 >10	-	-	-
S83222-25mg	98.4%	￥576.00 S83222-25mg ￥576.00 現(xiàn)貨	169 >10	-	-	-
S83222-100mg	98.4%	￥1080.00 S83222-100mg ￥1080.00 現(xiàn)貨	46 >10	-	-	-

產(chǎn)品介紹

GC376 是一種 3CLpro (3C-like protease) 的抑制劑，對于PEDV 3CLpro的IC50值約為1.11 μM。GC376 對多種冠狀病毒（包括SARS-CoV）的3CLpro有活性

產(chǎn)品描述：

GC376 是一種 3CLpro (3C-like protease) 的抑制劑，對于PEDV 3CLpro的IC50值約為1.11 μM。GC376 對多種冠狀病毒（包括SARS-CoV）的3CLpro有活性

靶點：

PEDV 3CLpro(Cell-free assay):1.11 μM;SARS-CoV

體外研究：

Molnupiravir and GC376 show a synergistic activity on SARS-CoV-2 at 48 h, and an additive activity on SARS-CoV-2 at 72 h

體內(nèi)研究：

GC376, a dipeptidyl bisulfite adduct salt, is a 3CLpro (3C-like protease) inhibitor that exerts strong inhibitory effects on picornaviruses and coronaviruses, including SARS-CoV.

細胞實驗：

Cell lines: Vero E6 cells Concentrations: 0.21-16.7 μM Incubation Time: 48 and 72 h Method: Vero E6 cells (3000 cells/well) were seeded in 96-well clear flat-bottom plates and incubated at 37°C with 5% CO2 for 24 h. After incubation, cells were infected using a multiplicity of infection (MOI) of 0.1. SARS-CoV-2 was allowed to adsorb for one hour at 37°C. Subsequently, virus inoculum was removed, and cells were overlaid with media containing 3-fold serial dilutions of molnupiravir (0.62-50 μM), nirmatrelvir (0.62-50 μM) and GC376 (0.21-16.7 μM). Negative controls (compounds alone), infected positive controls (SARS-CoV-2 alone) and mock-infected cells were included in each plate. Plates were incubated at 37°C with 5% CO2 for 48 and 72 h and then, cell viability was measured using an MTT reduction assay.

動物實驗：

Animal Models: Female BALB/c mice Dosages: 111 or 55.5 mg/kg Administration: i.m.

參考文獻：

1. Gang Ye, et al. Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376. Viruses. 2020 Feb 21;12(2):240. 2. Gidari A, et al. The Combination of Molnupiravir with Nirmatrelvir or GC376 Has a Synergic Role in the Inhibition of SARS-CoV-2 Replication In Vitro. Microorganisms. 2022 Jul 21;10(7):1475. 3. Shi Y, et al. The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract. Emerg Microbes Infect. 2021 Dec;10(1):481

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20℃，充氮保存

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.97 ml	9.852 ml	19.703 ml
5 mM	0.394 ml	1.97 ml	3.941 ml
10 mM	0.197 ml	0.985 ml	1.97 ml
50 mM	0.039 ml	0.197 ml	0.394 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(2篇)

2. [IF=3.7] Zunyun Jiang et al."Identifying Natural Products as Feline Coronavirus Mpro Inhibitors by Structural-Based Virtual Screening and Enzyme-Based Assays."ACS Omega.2025;10(2):2092–2101 1. [IF=14.903] Yang Yi et al."Schaftoside inhibits 3CLpro and PLpro of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19."Acta Pharmaceutica Sinica B.2022 Aug;:

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