貨號	規格	價格	上海	北京	武漢	南京
S82693-1mg	99.9%	￥425.00 S82693-1mg ￥425.00 現貨	5 5	-	-	-
S82693-5mg	99.9%	￥765.00 S82693-5mg ￥765.00 現貨	7 7	-	-	-
S82693-10mg	99.9%	￥1445.00 S82693-10mg ￥1445.00 現貨	5 5	-	-	-
S82693-25mg	≥99%	￥2465.00 S82693-25mg ￥2465.00 2-3天	0 貨期：2-3天	-	-	-
S82693-50mg	≥99%	￥4335.00 S82693-50mg ￥4335.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor with IC50 of 6.8 nM.

產品描述：

CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor with IC50 of 6.8 nM.

靶點：

PI3Kα:6.8 nM (IC50);PI3Kβ:166 nM (IC50);PI3Kδ:240.3 nM (IC50);PI3Kγ:3020 nM (IC50);PI3K

體外研究：

CNX-1351 is able to potently (EC50<100 nM) and specifically inhibit signaling in PI3Kα-dependent cancer cell lines, and this leads to a potent antiproliferative effect (GI50<100 nM). CNX-1351 inhibits PI3K signaling in SKOV3 cells, with potency (EC50 of 10-100 nM) similar to that of the pan-PI3K inhibitor. To investigate the functional consequence of inhibiting PI3Kα in cells, two cell lines with different PIK3CA activating mutations, SKOV3 ovarian cancer cells (H1047R) and MCF-7 breast cancer cells (E545K), are treated with CNX-1351 and growth is monitored. Both PIK3CA-driven cell lines are growth inhibited by exposure to CNX-1351 for 96 h (GI50 of 78 and 55 nM, respectively)

體內研究：

CNX-1351 inhibits p-AktSer473?in mouse spleens and bonds to PI3Kα in vivo. CNX-1351 is delivered into the intraperitoneal cavity of nude mice at 100 mg/kg once a day for 5 consecutive days (n=3 mice per group). Spleens are harvested from the mice at the indicated times after the last dose (1-24 h) and interrogated by immunoblot for P-AktSer473?or for PI3Kα occupancy. Inhibition of PI3K signaling is detected as a decrease in P-AktSer473?at 1 and 4 h after last dose

參考文獻：

1. Nacht M, et al. Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα. J Med Chem. 2013 Feb 14;56(3):712-21.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.743 ml	8.715 ml	17.43 ml
5 mM	0.349 ml	1.743 ml	3.486 ml
10 mM	0.174 ml	0.872 ml	1.743 ml
50 mM	0.035 ml	0.174 ml	0.349 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费