貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S82560-5mg	≥98%	￥2900.00 S82560-5mg ￥2900.00 2-3天	0 貨期：2-3天	-	-	-
S82560-10mg	≥98%	￥5350.00 S82560-10mg ￥5350.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

PI4KIII beta inhibitor 3 is a novel and high effective PI4KIIIβ inhibitor with IC50 of 5.7 nM.

產(chǎn)品描述：

PI4KIII beta inhibitor 3 is a novel and high effective PI4KIIIβ inhibitor with IC50 of 5.7 nM.

靶點：

PI4KIIIβ：5.7 nM (IC50);PI3K

體內(nèi)研究：

PI4KIII beta inhibitor 3 (40 mg/kg per day, n=12) is able to delay the onset of arthritic symptoms and also to decrease symptom severity in a preventive model of arthritis compared to a vehicle control (MC 1%, n=12). PI4KIII beta inhibitor 3 reduces the anti-CII IgG titre and histological scores in the collagen-induced arthritis mouse model. Oral administration of PI4KIII beta inhibitor 3 results in prolonged graft survival in 3 out of 6 grafts in each group at day 30. Several grafts continued beating after withdrawal of the treatment (up to 60 days), indicating the induction of a certain type of graft tolerance. To evaluate the operational tolerance phenotype, animals with functional graft at day 60 are challenged with a second graft from the same donor strain or from a third party. No treatment is applied. The second grafts from the third party are rejected at day 8 (n=2) whereas second grafts from the same donor strain are functional for more than 90 days (n=2)

參考文獻(xiàn)：

1. Jean Herman, et al. Autoimmune and inflammatory disorder therapy. From PCT Int. Appl. (2013), WO 2013034738 A1

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.239 ml	11.197 ml	22.395 ml
5 mM	0.448 ml	2.239 ml	4.479 ml
10 mM	0.224 ml	1.12 ml	2.239 ml
50 mM	0.045 ml	0.224 ml	0.448 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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PI4KIII beta inhibitor 3

4-(5-amino-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-7-yl)-N-p-tolylpiperazine-1-carboxamide