貨號	規格	價格	上海	北京	武漢	南京
S82515-5mg	99.4%	￥320.00 S82515-5mg ￥320.00 現貨	4 4	-	-	-
S82515-10mg	99.4%	￥432.00 S82515-10mg ￥432.00 現貨	6 6	-	-	-
S82515-25mg	99.4%	￥880.00 S82515-25mg ￥880.00 現貨	5 5	-	-	-
S82515-100mg	≥99%	￥2240.00 S82515-100mg ￥2240.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems

產品描述：

靶點：

IC50: 4541nM (5-HT3); EC50: 154 nM (α7 nAChR); Ki: 27 nM (R7 MLA);AChR

體外研究：

PNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM. PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM. PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM

體內研究：

PNU-282987 (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit. PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner. Animal Model: Rats Dosage: 1, 3 mg/kg Administration: i.v. Result: Significantly reversed amphetamine-induced gating deficit.

參考文獻：

1. Alice L Bodnar, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.777 ml	18.886 ml	37.771 ml
5 mM	0.755 ml	3.777 ml	7.554 ml
10 mM	0.378 ml	1.889 ml	3.777 ml
50 mM	0.076 ml	0.378 ml	0.755 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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PNU-282987

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE