貨號	規格	價格	上海	北京	武漢	南京	購買數量
S82236-5mg	≥98%	￥3500.00 S82236-5mg ￥3500.00 2-3天	0 貨期：2-3天	-	-	-
S82236-10mg	≥98%	￥5000.00 S82236-10mg ￥5000.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.

產品描述：

DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.

靶點：

DPP-4;Proteasome;Proteasome;?DPP-4

體外研究：

DBPR108 displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II.

體內研究：

DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes mellitus. The in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated.

參考文獻：

1. Yeh TK, et al. (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2010 Jun

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.083 ml	15.413 ml	30.827 ml
5 mM	0.617 ml	3.083 ml	6.165 ml
10 mM	0.308 ml	1.541 ml	3.083 ml
50 mM	0.062 ml	0.308 ml	0.617 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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