貨號	規(guī)格	價格	上海	北京	武漢	南京
S81722-1mg	99.8%	￥100.00 S81722-1mg ￥100.00 現(xiàn)貨	1 1	-	-	-
S81722-2mg	99.8%	￥180.00 S81722-2mg ￥180.00 現(xiàn)貨	1 1	-	-	-
S81722-5mg	99.8%	￥280.00 S81722-5mg ￥280.00 現(xiàn)貨	4 4	-	-	-
S81722-10mg	99.8%	￥320.00 S81722-10mg ￥320.00 現(xiàn)貨	12 >10	-	-	-
S81722-25mg	99.8%	￥370.00 S81722-25mg ￥370.00 現(xiàn)貨	4 4	-	-	-
S81722-50mg	99.8%	￥600.00 S81722-50mg ￥600.00 現(xiàn)貨	4 4	-	-	-
S81722-100mg	99.8%	￥1000.00 S81722-100mg ￥1000.00 現(xiàn)貨	5 5	-	-	-

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產(chǎn)品介紹

Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease

產(chǎn)品描述：

靶點：

αLβ2;Integrin

體外研究：

Lifitegrast (SAR 1118) inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses. Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM

體內(nèi)研究：

Lifitegrast (SAR 1118), has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior. Lifitegrast (SAR 1118) ophthalmic drops administered thrice daily deliver therapeutic levels of Lifitegrast (SAR 1118) in the retina and can alleviate the retinal complications associated with diabetes

參考文獻(xiàn)：

1. Perez VL, et al. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 Apr;14(2):207-15. 2. Sun Y, et al. Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May;29(4):395-402. 3. Rao VR, et al. Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin(STZ) model of diabetic retinopathy (DR). Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5198-204.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.625 ml	8.124 ml	16.247 ml
5 mM	0.325 ml	1.625 ml	3.249 ml
10 mM	0.162 ml	0.812 ml	1.625 ml
50 mM	0.032 ml	0.162 ml	0.325 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(1篇)

1. [IF=4.411] Xin Meng et al."Drug Repurposing for Influenza Virus Polymerase Acidic (PA) Endonuclease Inhibitor."Molecules. 2021 Jan;26(23):7326

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