貨號	規(guī)格	價格	上海	北京	武漢	南京
S81602-5mg	≥98%	￥1200.00 S81602-5mg ￥1200.00 2-3天	0 貨期：2-3天	-	-	-
S81602-10mg	≥98%	￥1900.00 S81602-10mg ￥1900.00 2-3天	0 貨期：2-3天	-	-	-
S81602-25mg	≥98%	￥3900.00 S81602-25mg ￥3900.00 2-3天	0 貨期：2-3天	-	-	-
S81602-50mg	≥98%	￥6600.00 S81602-50mg ￥6600.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens.

產(chǎn)品描述：

Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens.

靶點：

acterial;Antibacterial

體外研究：

Enmetazobactam shows potent activity against specific resistance phenotypes with MIC50 and MIC90 of 0.125 mg/L and 64 mg/L. Cefepime-Enmetazobactam MICs decreases with increasing concentrations of Enmetazobactam (over the range from 1 to 16 mg/L) for most strains, demonstrating a concentration dependence of Enmetazobactam on restoration of the antibacterial activity of the cephalosporin

體內(nèi)研究：

In neutropenic animals, cefepime-Enmetazobactam treatment results in reductions in bacterial density of ≥0.5 log10 CFU for 12 of the 20 strains tested and reductions of ≥1 log10 CFU for 6 of these. Increases in bacterial density are for only four strains, three of which have cefepime-Enmetazobactam MICs of ≥64 mg/L, irrespective of the Enmetazobactam concentration

參考文獻：

1. Crandon JL, et al. In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae. Pathogens. 2015 Aug 18;4(3):620-5. 2. Crandon JL, et al. In vivo activities of simulated human doses of cefepime and cefepime-AAI101 against multidrug-resistant Gram-negative Enterobacteriaceae. Antimicrob Agents Chemother. 2015 May;59(5):2688-94.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.181 ml	15.907 ml	31.815 ml
5 mM	0.636 ml	3.181 ml	6.363 ml
10 mM	0.318 ml	1.591 ml	3.181 ml
50 mM	0.064 ml	0.318 ml	0.636 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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