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CGI-1746

    
96%

CGI-1746

源葉(MedMol)
S81560 一鍵復(fù)制產(chǎn)品信息
910232-84-7
C34H37N5O4
579.71
貨號(hào) 規(guī)格 價(jià)格 上海 北京 武漢 南京 購(gòu)買(mǎi)數(shù)量
S81560-1mg 96% ¥297.50 10 - - -
S81560-5mg 96% ¥510.00 8 - - -
S81560-10mg 96% ¥935.00 6 - - -
S81560-25mg 96% ¥2040.00 6 - - -
S81560-50mg 96% ¥2720.00 貨期:2-3天 - - -
S81560-100mg 96% ¥4700.00 貨期:2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(shū)(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

CGI-1746 is a potent and highly selective inhibitor of the Btk with IC50 of 1.9 nM.

產(chǎn)品描述: CGI-1746 is a potent and highly selective inhibitor of the Btk with IC50 of 1.9 nM.
靶點(diǎn): IC50: 1.9 nM (Btk);BTK;?Autophagy
體內(nèi)研究: CGI1746 abrogates B cell-dependent arthritis. CGI1746 treatment (100 mg/kg, s.c, twice-daily dosing) results in significant inhibition (97%) of overall clinical arthritis scores. CGI1746 treatment substantially reduces TNFα, IL-1β and IL-6, as well as MCP1 and MIP-1α on both the mRNA and protein level in the passive anti-collagen II antibody-induced arthritis (CAIA) model. CGI1746 shows comparable efficacy to TNFα blockade and significantly reduces clinical scores, as well as joint inflammation, in mice or rats with established arthritis
參考文獻(xiàn): 1. Di Paolo, Julie A. et al. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nature Chemical Biology (2011), 7(1), 41-50 2. Kokabee L, et al. Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol Ther. 2015;16(11):1604-15
溶解性: DMSO  :  ≥  50  mg/mL  (86.25  mM)
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 1.725 ml 8.625 ml 17.25 ml
5 mM 0.345 ml 1.725 ml 3.45 ml
10 mM 0.173 ml 0.863 ml 1.725 ml
50 mM 0.035 ml 0.173 ml 0.345 ml
注意: 部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(shū)(COA)

如何獲取質(zhì)檢證書(shū)(COA)?
請(qǐng)輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
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批號(hào):JS298415 貨號(hào):S20001-25g
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摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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