品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
源葉(MedMol)	S81503-1mg	99%	￥240.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S81503-5mg	99%	￥400.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S81503-10mg	99%	￥530.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S81503-25mg	99%	￥970.00元	3	-	-	-
源葉(MedMol)	S81503-50mg	99%	￥1680.00元	預(yù)計(jì)交期：2-3天	-	-	-

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產(chǎn)品介紹

Vorapaxar (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).

產(chǎn)品描述：

Vorapaxar (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).

靶點(diǎn)：

Protease-activated Receptor;Protease-activatedReceptor

體內(nèi)研究：

SCH 530348 is well absorbed in rat (68%; 10 mg/kg) and in monkey (82%; 1 mg/kg) models. Tmax is observed at about 3 h in rats and 1 h in monkeys. The elimination half-life is 5.1 h in rats and 13 h in monkeys. The oral bioavailability is 33% in rats and 86% in monkeys. In preclinical studies in cynomolgus monkey platelets, oral administration of SCH 530348 at a dose greater than 0.1 mg/kg resulted in 100% inhibition of thrombin-receptor agonist peptide (TRAP)-induced platelet aggregation for 24 h with partial recovery occurring at 48 h.

參考文獻(xiàn)：

1.Chackalamannil S, et al. J Med Chem, 2008, 51(11), 3061-3064. 2.Tang W, Huang B, Wang J, et al. A label-free screening approach targeted protease-activated receptor 1 based on dynamic mass redistribution in living cells[J]. RSC Advances. 2017, 7(68): 43005-43013.

溶解性：

H2O:<1 mg/mL Ethanol:92 mg/mL (186.8 mM) DMSO:92 mg/mL (186.8 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.03 ml	10.151 ml	20.301 ml
5 mM	0.406 ml	2.03 ml	4.06 ml
10 mM	0.203 ml	1.015 ml	2.03 ml
50 mM	0.041 ml	0.203 ml	0.406 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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VORAPAXAR

Vorapaxar