貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京	購(gòu)買數(shù)量
S81489-100mg	99.5%	￥120.00 S81489-100mg ￥120.00 現(xiàn)貨	2 2	-	-	-
S81489-500mg	99.5%	￥224.00 S81489-500mg ￥224.00 現(xiàn)貨	6 6	-	-	-

產(chǎn)品介紹

Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

產(chǎn)品描述：

Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

靶點(diǎn)：

Glucokinase;Microtubule Associated;Parasite;Glucokinase;?MicrotubuleAssociated;?Parasite

體內(nèi)研究：

Oxfendazole (OX) induces not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1 in rats, presumably due to an adaptive response against OX-induced oxidative stress. Oxfendazole enhances oxidative DNA damage (as assessed by 8-hydroxydeoxyguanosine; 8-OHdG) and lipid peroxidation (as assessed by thiobarbituric acid-reactive substances; TBARS) in rats. Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increase 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95% and 184% increases) in rabbit liver. Oxfendazole MRL induces a mutagenic effect in all tested cell types. Oxfendazole exhibits embryotoxicity including teratogenicity. Oxfendazole induces a disturbance in the different biochemical contents of all tested tissues in mice. Oxfendazole increases the incidence and multiplicity of altered foci (4.0- and 3.6-fold, respectively) and hepatocellular adenomas (HCAs) (3.0- and 5.5-fold, respectively). Oxfendazole treatment induces 5.2- and 5.6-fold increases in the number of proliferating cell nuclear antigen (PCNA)-positive cells and single-stranded DNA (ssDNA)-positive cells in HCAs compared with the surrounding tissue, respectively. Oxfendazole and its sulphone metabolite attain a significantly higher plasma concentration and remain much longer in plasma compared with fenbendazole (FBZ) and albendazole (ABZ) and

參考文獻(xiàn)：

1.Dewa Y, et al. Arch Toxicol,2009, 83(5), 503-511. 2.Dewa Y, et al. Arch Toxicol,2011, 85(2), 155-162. 3.El-Makawy A, et al. Reprod Nutr Dev,2006, 46(2), 139-156. 4.Gokbulut C, et al. Vet Parasitol,2007, 148(3-4), 279-287. 5.Gleizes C, et al. Biochem Pharmacol,1991, 41(12), 1813-1820.

溶解性：

Ethanol:<1 mg/mL H2O:<1 mg/mL DMSO:10 mg/mL (31.71 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.171 ml	15.855 ml	31.711 ml
5 mM	0.634 ml	3.171 ml	6.342 ml
10 mM	0.317 ml	1.586 ml	3.171 ml
50 mM	0.063 ml	0.317 ml	0.634 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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