| 產品描述： | (-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM. |
| 靶點： |
Human Endogenous Metabolite;EstrogenReceptor/ERR;?Estrogen/progestogenReceptor;?EndogenousMetabolite |
| 體內研究： |
(-)-(S)-Equol inhibits the tumor growth by 43.2% and 28.4% compared to the control on day 33, suggesting that the compound is not overtly toxic |
| 參考文獻： |
1. Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9. 2. Lu Z, et al. S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway. Curr Cancer Drug Targets. 2016;16(5):455-65. 3. Horiuchi H, et al. S-equol nantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells. J Nutr Sci Vitaminol (Tokyo). 2014;60(4):291-6. |
| 溶解性： |
DMSO : 100 mg/mL (412.76 mM; Need ultrasonic and warming) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
4.128 ml |
20.638 ml |
41.276 ml |
| 5 mM |
0.826 ml |
4.128 ml |
8.255 ml |
| 10 mM |
0.413 ml |
2.064 ml |
4.128 ml |
| 50 mM |
0.083 ml |
0.413 ml |
0.826 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京