貨號	規(guī)格	價格	上海	北京	武漢	南京
S81428-2mg	99.7%	￥240.00 S81428-2mg ￥240.00 現貨	9 9	-	-	-
S81428-5mg	99.7%	￥385.00 S81428-5mg ￥385.00 現貨	10 10	-	-	-
S81428-10mg	99.7%	￥660.00 S81428-10mg ￥660.00 現貨	8 8	-	-	-
S81428-25mg	99.7%	￥1160.00 S81428-25mg ￥1160.00 現貨	9 9	-	-	-
S81428-50mg	99.7%	￥1810.00 S81428-50mg ￥1810.00 現貨	6 6	-	-	-
S81428-100mg	99.7%	￥3000.00 S81428-100mg ￥3000.00 現貨	3 3	-	-	-

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產品介紹

AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding

產品描述：

靶點：

IC50: 8.8 μM (PRMT1), 3.0 μM (yeast-Hmt1p);HistoneMethyltransferase

體內研究：

AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo. AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model. AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model

參考文獻：

1. Zhang, B., et al. Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. Oncotarget. 2015 Sep 8;6(26):22799-811. 2. Baolai Zhang, et al. Arginine Methyltransferase inhibitor-1 Inhibits Sarcoma Viability in vitro and in vivo. Oncol Lett. 2018 Aug;16(2):2161-2166. 3. Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9.

溶解性：

H2O : 62.5 mg/mL (113.96 mM; ultrasonic and warming and heat to 60°C)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.823 ml	9.117 ml	18.233 ml
5 mM	0.365 ml	1.823 ml	3.647 ml
10 mM	0.182 ml	0.912 ml	1.823 ml
50 mM	0.036 ml	0.182 ml	0.365 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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AMI-1

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)