貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81410-5mg	98.7%	￥270.00 S81410-5mg ￥270.00 現(xiàn)貨	6 6	-	-	-
S81410-10mg	98.7%	￥400.00 S81410-10mg ￥400.00 現(xiàn)貨	6 6	-	-	-
S81410-50mg	98.7%	￥1060.00 S81410-50mg ￥1060.00 現(xiàn)貨	3 3	-	-	-

產(chǎn)品介紹

AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

產(chǎn)品描述：

靶點(diǎn)：

12G5 mAb-CXCR4:0.75 nM (IC50, in SupT1 cells);CXCL12AF647-CXCR4:18 nM (IC50, in SupT1 cells);X4 HIV-1 (NL4.3):6.1 nM (IC50, in MT-4 cells);X4 HIV-1 (RF):7.4 nM (IC50, in MT-4 cells);X4 HIV-1 (HE):9.8 nM (IC50, in MT-4 cells);X4 HIV-1 (IIIB):12.3 nM (IC50, in MT-4 cells);X4 HIV-1 (NL4.3AMD3100):2822 nM (IC50, in MT-4 cells);HIV-2 (ROD):12.3 nM (IC50, in MT-4 cells);HIV-2 (EHO):12.3 nM (IC50, in MT-4 cells);HIVProtease

體內(nèi)研究：

AMD 3465 (2.5 mg/kg/d, s.c. for 5 weeks) significantly blocks the growth of U87 GBM and Daoy xenografts

參考文獻(xiàn)：

1. Hatse S, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol. 2005 Sep 1;70(5):752-61. 2. Yang L, et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15;67(2):651-8.

溶解性：

DMSO : 50 mg/mL (55.80 mM; Need ultrasonic) H2O : ≥ 38 mg/mL (42.41 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.116 ml	5.58 ml	11.16 ml
5 mM	0.223 ml	1.116 ml	2.232 ml
10 mM	0.112 ml	0.558 ml	1.116 ml
50 mM	0.022 ml	0.112 ml	0.223 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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