貨號	規格	價格	上海	北京	武漢	南京
S81396-5mg	≥98%(HPLC)	￥601.00 S81396-5mg ￥601.00 現貨	4 0 4	-	-	-
S81396-10mg	≥98%(HPLC)	￥1030.00 S81396-10mg ￥1030.00 現貨	5 5	-	-	-
S81396-25mg	≥98%(HPLC)	￥2038.00 S81396-25mg ￥2038.00 現貨	5 5	-	-	-
S81396-50mg	≥98%(HPLC)	￥3624.00 S81396-50mg ￥3624.00 現貨	6 6	-	-	-
S81396-100mg	≥98%(HPLC)	￥5218.00 S81396-100mg ￥5218.00 現貨	5 5	-	-	-

產品介紹

I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways

產品描述：

靶點：

Epigenetic Reader Domain;EpigeneticReaderDomain

體外研究：

I-BRD9 (10 μM, 6 h) has a regulation role in cancer and immunology pathways. I-BRD9 (10 μM) has high BRD9 affinity and excellent broader bromodomain selectivity. I-BRD9 (10 μM) has affinity for BRD9 (TR-FRET), BRD4 BD1 (TR-FRET) and BRD9 NanoBRET with pIC50 values of 7.3 μM, 5.3 μM and 6.8 μM. I-BRD9 (10 μM) has high aqueous solubility (CLND) with 359 μM. I-BRD9 (10 μM) displays >625 fold selectivity in binding with endogenous BRD9 against BET family member BRD3 in HUT-78 cell lysate. RT-PCR Cell Line: Kasumi-1 cells Concentration: 10 μM Incubation Time: 6 h Result: Showed 4 genes (CLEC1, 62 DUSP6, 63 FES64 and SAMSN165) that were strongly down-regulated and not by I-BET151.

參考文獻：

1. Natalie H Theodoulou, et al. Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J Med Chem

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.01 ml	10.049 ml	20.098 ml
5 mM	0.402 ml	2.01 ml	4.02 ml
10 mM	0.201 ml	1.005 ml	2.01 ml
50 mM	0.04 ml	0.201 ml	0.402 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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