貨號	規(guī)格	價格	上海	北京	武漢	南京
S81352-5mg	99.5%	￥350.00 S81352-5mg ￥350.00 現(xiàn)貨	6 6	-	-	-
S81352-10mg	99.5%	￥660.00 S81352-10mg ￥660.00 現(xiàn)貨	7 7	-	-	-
S81352-25mg	99.5%	￥1530.00 S81352-25mg ￥1530.00 現(xiàn)貨	5 5	-	-	-
S81352-50mg	99.5%	￥2650.00 S81352-50mg ￥2650.00 現(xiàn)貨	6 6	-	-	-

產(chǎn)品介紹

Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity

產(chǎn)品描述：

靶點：

IC50: 10 μM (TrKA phosphorylation) IC50: 1 μM (ErbB2);Apoptosis;?EGFR;?Trkreceptor;?HER;?PDGFR

體內(nèi)研究：

Tyrphostin AG 879 (100 mg/kg;subcutaneous injection; administered 10 times in 19 days; for 21 days; athymic, immunodepressed NOD/SCID female mice) treatment induces in vivo a decrease in cancer growth in grafted athymic NOD/SCID mice

參考文獻：

1. Rende M et al. Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo stud 2. Zhou Y et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 2006 Jan 1;66(1):404-11. 3. Levitzki A, et al. Tyrosine kinase inhibition: an approach to drug development. Science. 1995 Mar 24;267(5205):1782-8.

溶解性：

DMSO : 50 mg/mL (158.00 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.16 ml	15.8 ml	31.6 ml
5 mM	0.632 ml	3.16 ml	6.32 ml
10 mM	0.316 ml	1.58 ml	3.16 ml
50 mM	0.063 ml	0.316 ml	0.632 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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