貨號	規(guī)格	價格	上海	北京	武漢	南京
S81205-2mg	99.0%	￥60.00 S81205-2mg ￥60.00 現(xiàn)貨	9 9	-	-	-
S81205-5mg	99.0%	￥70.00 S81205-5mg ￥70.00 現(xiàn)貨	7 7	-	-	-
S81205-10mg	99.0%	￥120.00 S81205-10mg ￥120.00 現(xiàn)貨	3 3	-	-	-
S81205-25mg	99.0%	￥290.00 S81205-25mg ￥290.00 現(xiàn)貨	9 9	-	-	-
S81205-100mg	99.0%	￥590.00 S81205-100mg ￥590.00 現(xiàn)貨	7 7	-	-	-

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產(chǎn)品介紹

Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).

產(chǎn)品描述：

Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).

靶點：

Apoptosis;EGFR;HER;Apoptosis;?EGFR;?HER

體內(nèi)研究：

Poziotinib對EGFR磷酸化和下游信號級聯(lián)放大的關(guān)鍵組分有抑制作用,如STAT3,AKT和ERK,且對HER2擴增的胃癌細(xì)胞生長有特異性抑制效果。經(jīng)激活HER2擴增的胃癌細(xì)胞中線粒體途徑,Poziotinib還可誘導(dǎo)G1細(xì)胞周期阻滯和細(xì)胞凋亡。此外,在HER2誘發(fā)的和HER2非擴增的胃癌細(xì)胞中,Poziotinib與化療劑有協(xié)同效果

細(xì)胞實驗：

Viable cell growth is determined by an MTT reduction assay. Briefly, all cell lines are seeded at a density of 3 × 103 per well in 96-well culture plates and then incubated at 37 °C for 24 h. The cells are then treated with 0.001, 0.01, 0.1, or 10 μM of HM781-36B. Three days later, 50 μg of MTT are added to each well and the samples are then incubated for 4 h to reduce the dye. Next, the samples are treated with DMSO, after which the absorbance of the converted dye in the living cells is measured at a wavelength of 540 nm. Six replicate wells are used for each analysis, and at least three independent experiments are conducted. Data points shown represent the mean while bars represent the SE.(Only for Reference)

參考文獻：

1.Nam HJ, et al. Cancer Lett. 2011, 302(2), 155-165. 2.Cha MY, et al. Int J Cancer. 2012, 130(10), 2445-2454.

溶解性：

H2O:<1 mg/mL DMSO:91 mg/mL (185.2 mM) Ethanol:<1 mg/mL

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.035 ml	10.176 ml	20.352 ml
5 mM	0.407 ml	2.035 ml	4.07 ml
10 mM	0.204 ml	1.018 ml	2.035 ml
50 mM	0.041 ml	0.204 ml	0.407 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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Poziotinib (HM781-36B)