品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
源葉(MedMol)	S81150-1mg	99%	￥216.00元	5	-	-	-
源葉(MedMol)	S81150-2mg	99%	￥384.00元	5	-	-	-
源葉(MedMol)	S81150-5mg	99%	￥440.00元	5	-	-	-
源葉(MedMol)	S81150-10mg	99%	￥720.00元	5	-	-	-
源葉(MedMol)	S81150-25mg	99%	￥1440.00元	4	-	-	-
源葉(MedMol)	S81150-50mg	99%	￥2160.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S81150-100mg	99%	￥3920.00元	預(yù)計(jì)交期：2-3天	-	-	-

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產(chǎn)品介紹

JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.

產(chǎn)品描述： JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.

靶點(diǎn)： c-Met/HGFR

體內(nèi)研究：
In mice bearing established GTL16 xenografts, JNJ-38877605 (40 mg/kg/day, p.o., total 3day) results in a statistically marked decrease in the plasma levels of human IL-8 (0.150-0.050 ng/mL) and GROα (0.080-0.030 ng/mL). While concentrations of uPAR in the blood become reduced to more than 50% at the same dose.

動(dòng)物實(shí)驗(yàn)： Animal Models: GTL16 cells are inoculated subcutaneously into the right posterior flank (or both right and left posterior flanks,for determination of uPAR and IL-6) of 6-week-old immuno-deficient nu/nu female mice on Swiss CD1 background. Formulation: JNJ-38877605 is dissolved in PBS. Dosages: ≤40 mg/kg/day. Administration: Administered via p.o.

參考文獻(xiàn)：
1.De Bacco F, et al. J Natl Cancer Inst. 2011 Apr, 103(8), 645-661. 2.Torti D, et al. Int J Cancer. 2012, 130(6), 1357-1366.

溶解性： H2O:<1 mg/mL Ethanol:<1 mg/mL DMSO:35 mg/mL (92.8 mM)

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.65 ml	13.25 ml	26.501 ml
5 mM	0.53 ml	2.65 ml	5.3 ml
10 mM	0.265 ml	1.325 ml	2.65 ml
50 mM	0.053 ml	0.265 ml	0.53 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

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