貨號	規格	價格	上海	北京	武漢	南京
S80994-5mg	99.9%	￥172.00 S80994-5mg ￥172.00 現貨	8 8	-	-	-
S80994-25mg	99.9%	￥300.00 S80994-25mg ￥300.00 現貨	10 10	-	-	-
S80994-100mg	99.9%	￥760.00 S80994-100mg ￥760.00 現貨	10 10	-	-	-
S80994-500mg	99.9%	￥1800.00 S80994-500mg ￥1800.00 現貨	5 5	-	-	-
S80994-1g	99.9%	￥2800.00 S80994-1g ￥2800.00 現貨	2 2	-	-	-

產品介紹

Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis

產品描述：

靶點：

VEGFR2:0.035 nM (IC50);Flt-4:6 nM (IC50);Flt-1:12 nM (IC50);VEGFR;FLT;c-Met/HGFR;TAMReceptor;c-Kit;ROR

體內研究：

Cabozantinib (100 mg/kg, Orally, once) inhibits MET and VEGFR2 phosphorylation in mice. Cabozantinib (100 mg/kg, Orally, once) significantly increases tumor hypoxia and apoptosis. Cabozantinib (0-60 mg/kg, Orally, once daily for 14 days) inhibits tumor growth in a dose-dependent manner.

參考文獻：

1. Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308. 2. You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768. 3. Fuse MA, et al. Combination Therapy With c-Met and Src Inhibitors Induces Caspase-Dependent Apoptosis of Merlin-Deficient Schwann Cells and Suppresses Growth of Schwannoma Cells. Mol Cancer Ther. Mol Cancer Ther. 2017 Nov;16(11):2387-2398.

溶解性：

DMSO : 25 mg/mL (49.85 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.994 ml	9.97 ml	19.939 ml
5 mM	0.399 ml	1.994 ml	3.988 ml
10 mM	0.199 ml	0.997 ml	1.994 ml
50 mM	0.04 ml	0.199 ml	0.399 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费

Cabozantinib (XL184, BMS-907351)