品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
源葉(MedMol)	S80923-100mg	98%	￥140.00元	>10	-	-	-
源葉(MedMol)	S80923-500mg	98%	￥300.00元	>10	-	-	-
源葉(MedMol)	S80923-1g	98%	￥450.00元	>10	-	-	-

產(chǎn)品介紹

Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research

產(chǎn)品描述： Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research

靶點(diǎn)： COX-1:20 nM (IC50);COX-2:120 nM (IC50);DDX3;COX

體內(nèi)研究：
Ketorolac (RS37619) (0.4% ketorolac tromethamine ophthalmic solution) shows powerful ocular anti-inflammatory activities in rabbits. Ketorolac (4 mg/kg/day, p.o.; 2 weeks) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats. Ketorolac (60 μg; intrathecal injection; once) attenuates the damage caused by spinal cord ischemia in rats. Ketorolac salt (20 and 30 mg/kg; i.p.; two times in a week for 3 weeks) reduces oral carcinogenesis in mice.

參考文獻(xiàn)：
1. Waterbury LD, et al. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40. 2. Fracon RN, et al. Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec;18(6):630-4. 3. Hsieh YC, et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr;100(4):1134-9. 4. Samal SK, et al. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Sci Rep. 2015 Apr 28;5:9982.

保存條件： 2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	0 ml	0 ml	0 ml
5 mM	0 ml	0 ml	0 ml
10 mM	0 ml	0 ml	0 ml
50 mM	0 ml	0 ml	0 ml

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參考文獻(xiàn)

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Ketorolac 98%

Ketorolac trometamol for peak identification