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產品描述： Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice. |
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靶點：
MAO-A:6.061 (IC50);MAO;MonoamineOxidase |
體內研究：
Moclobemide is a monoamine oxidase inhibitor and increases the levels of brain monoamines (such as 5-HT, norepinephrine).Moclobemide(40 mg/kg) is effective in animal behavior models |
參考文獻：
1. Nafiz ?ncü Can, et al. Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity. Molecules. 2017 Aug 20;22(8):1381. 2. Yun-feng Li, et al. Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice. Acta Pharmacol Sin. 2004 Nov;25(11):1408-12. |
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溶解性：
DMSO : 100 mg/mL (372.11 mM; Need ultrasonic) |
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保存條件：
2-8℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
3.721 ml |
18.605 ml |
37.211 ml |
| 5 mM |
0.744 ml |
3.721 ml |
7.442 ml |
| 10 mM |
0.372 ml |
1.861 ml |
3.721 ml |
| 50 mM |
0.074 ml |
0.372 ml |
0.744 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京