| 產(chǎn)品描述： | Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. |
| 靶點(diǎn)： |
Topoisomerase II;Topoisomerase |
| 參考文獻(xiàn)： |
1. Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20(7):995-1003. 2. Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47(4):1040-4. 3. Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6(2):79-85. |
| 溶解性： |
DMSO : 41.67 mg/mL (147.07 mM; Need ultrasonic) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.529 ml |
17.647 ml |
35.295 ml |
| 5 mM |
0.706 ml |
3.529 ml |
7.059 ml |
| 10 mM |
0.353 ml |
1.765 ml |
3.529 ml |
| 50 mM |
0.071 ml |
0.353 ml |
0.706 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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