貨號	規格	價格	上海	北京	武漢	南京
S80900-2mg	99.9%	￥240.00 S80900-2mg ￥240.00 現貨	5 5	-	-	-
S80900-5mg	99.9%	￥400.00 S80900-5mg ￥400.00 現貨	7 7	-	-	-
S80900-10mg	99.9%	￥650.00 S80900-10mg ￥650.00 現貨	6 6	-	-	-
S80900-25mg	99.9%	￥1200.00 S80900-25mg ￥1200.00 現貨	6 6	-	-	-
S80900-50mg	99.9%	￥2100.00 S80900-50mg ￥2100.00 現貨	5 5	-	-	-
S80900-100mg	99.9%	￥3800.00 S80900-100mg ￥3800.00 現貨	5 5	-	-	-

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產品介紹

CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.

產品描述：

CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.

靶點：

Aurora A:8 nM (Ki);Aurora B:9.2 nM (Ki)

體內研究：

Oral administration of CYC-116 at dose levels of 75 and 100 mg/kg q.d. causes tumor growth delays of 2.3 and 5.8 days, which translates into specific growth delays of 0.32 and 0.81, respectively. The mean relative tumor volumes of mice receiving CYC-116 at both dose levels are less than those of vehicle-treated mice for the duration of the study period. At 100 mg/kg po q.d., the reduction in growth is statistically significant on days 6 and 9

參考文獻：

1. Wang S, et al. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53(11):4367-78.

溶解性：

DMSO : 15 mg/mL (40.71 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.714 ml	13.57 ml	27.14 ml
5 mM	0.543 ml	2.714 ml	5.428 ml
10 mM	0.271 ml	1.357 ml	2.714 ml
50 mM	0.054 ml	0.271 ml	0.543 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=5.988] Qun Wang et al."Study on the liver Drug’s dominant metabolic enzymes for six effective components of the Huang qi Liuyi decoction."Frontiers in Pharmacology.2023; 14: 1175896

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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CYC116