貨號	規格	價格	上海	北京	武漢	南京
S80891-5mg	99.6%	￥1105.00 S80891-5mg ￥1105.00 現貨	1 1	-	-	-
S80891-10mg	99.6%	￥1870.00 S80891-10mg ￥1870.00 現貨	6 6	-	-	-
S80891-25mg	99.6%	￥3655.00 S80891-25mg ￥3655.00 現貨	4 4	-	-	-

產品介紹

Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor

產品描述：

Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor

靶點：

Calcium channel blocker P-glycoprotein (P-gp) inhibitor;CalciumChannel;P-gp;DrugMetabolite

體內研究：

Norverapamil hydrochloride (9 mg/kg; p.o.), a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng?h/ml, and 41.6 ng/mL, respectively

參考文獻：

1. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66. 2. Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82. 3. Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302 4. Choi DH, et al. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):163-8.

溶解性：

H2O : ≥ 50 mg/mL (104.81 mM) DMSO : ≥ 31 mg/mL (64.98 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.096 ml	10.481 ml	20.963 ml
5 mM	0.419 ml	2.096 ml	4.193 ml
10 mM	0.21 ml	1.048 ml	2.096 ml
50 mM	0.042 ml	0.21 ml	0.419 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Nor Verapamil Hydrochloride