貨號	規格	價格	上海	北京	武漢	南京
S80875-5mg	99.9%	￥150.00 S80875-5mg ￥150.00 現貨	6 6	-	-	-
S80875-10mg	99.9%	￥290.00 S80875-10mg ￥290.00 現貨	6 6	-	-	-
S80875-25mg	99.9%	￥480.00 S80875-25mg ￥480.00 現貨	6 6	-	-	-
S80875-100mg	≥99%	￥1350.00 S80875-100mg ￥1350.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.

產品描述：

TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.

靶點：

PI3K

體外研究：

在小鼠模型中,TGX-221能夠改善血流量,增加尾出血和腎出血時間

體內研究：

在J774.2巨噬細胞中,TGX-221能夠抑制胰島素誘導的PKB的Ser473的磷酸化。在體外循環（ECC）模型中, TGX-221抑制血小板-ECC相互作用,血小板聚集和血小板 - 粒細胞結合。在PC3細胞中,TGX-221（0.2-20 μM）能夠抑制細胞增殖,降低p110βPI3K亞型的活性

細胞實驗：

For measurement of proliferation, cells are seeded in triplicate in 96-well culture plates and incubated overnight to allow cell attachment. The cells are incubated with TGX-221 for 24, 48, and 72 hours. At designated time intervals, cells are quantified by a crystal violet staining-based colorimetric assay. Briefly, cells are fixed by addition of 100 μl of 2.5% glutaraldehyde solution and incubated at room temperature for 30 minutes. Plates are washed three times by submersion in PBS solution. Plates are air-dried and stained by addition of 100 μL of 0.1% solution of crystal violet dissolved in deionized water and incubated for 20 minutes at room temperature, excess dye is removed by extensive washing with deionized water, and plates are air-dried prior to bound dye solubilization in 100 μL of 10% acetic acid. The optical density of dye extracts is measured directly in plates using a microplate reader at 570 nm.(Only for Reference)

參考文獻：

1. Straub A, et al. Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation. Thromb Haemost. 2008, 99(3), 609-615. 2. Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007, 404(3), 449-458. 3. Bird JE, et al. Bleeding response induced by anti-thrombotic doses of a phosphoinositide 3-kinase (PI3K)-β inhibitor in mice. Thromb Res. 2011, 127(6), 560-564. 4. Jackson SP, et al. PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med. 2005, 11(5), 507-514. 5. Lu XY, et al. Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines. Appl Microbiol Biotechnol. 2011, 89(5), 1423-1433.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.744 ml	13.719 ml	27.439 ml
5 mM	0.549 ml	2.744 ml	5.488 ml
10 mM	0.274 ml	1.372 ml	2.744 ml
50 mM	0.055 ml	0.274 ml	0.549 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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