貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80835-1mg	99.6%	￥180.00 S80835-1mg ￥180.00 現(xiàn)貨	9 9	-	-	-
S80835-5mg	99.6%	￥632.00 S80835-5mg ￥632.00 現(xiàn)貨	6 6	-	-	-
S80835-10mg	99.6%	￥960.00 S80835-10mg ￥960.00 現(xiàn)貨	5 5	-	-	-
S80835-50mg	99.6%	￥3040.00 S80835-50mg ￥3040.00 現(xiàn)貨	3 3	-	-	-
S80835-100mg	≥99%	￥4500.00 S80835-100mg ￥4500.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.

產(chǎn)品描述：

AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.

靶點(diǎn)：

GSK-3α:8.2 (pKi);GSK-3β:7.5 (pKi);cdk5:6.4 (pKi);cdk2:5.9 (pKi);cdk1:5.7 (pKi);GSK-3

體內(nèi)研究：

The pharmacokinetic analysis in blood after oral administration revealed that AZD1080 has a good oral bioavailability in rats (15-24%) with a half-life of 7.1 h, making AZD1080 attractive for further in vivo testing. The subchronic (3 days) oral treatment with AZD1080 at 4 or 15 μmol/kg significantly blocked the MK-801-induced memory deficit (AZD1080 vs. MK-801, p<0.05 at 4 μmol/kg and p<0.01 at 15 μmol/kg) in mice, raising the hypothesis that longer treatment may be required to prime the synapses to function effectively

參考文獻(xiàn)：

1. Georgievska B, et al. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem. 2013 May;125(3):446-56.

溶解性：

DMSO : 21.35 mg/mL (63.85 mM; Need ultrasonic and warming)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.991 ml	14.953 ml	29.907 ml
5 mM	0.598 ml	2.991 ml	5.981 ml
10 mM	0.299 ml	1.495 ml	2.991 ml
50 mM	0.06 ml	0.299 ml	0.598 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

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AZD1080

1H-Indole-5-carbonitrile, 2-hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-