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Tranilast

    
99%(HPLC)

Tranilast

源葉(MedMol)
S80787 一鍵復制產品信息
53902-12-8
C18H17NO5
327.33
曲尼司特;N-3,4-二甲基氧基肉桂酰-鄰氨基苯甲酸;N-(3',4'-Dimethoxycinnamoyl)anthranilic acid;Midazolam;2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid;2-((3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl)amino)ben
貨號 規格 價格 上海 北京 武漢 南京 購買數量
S80787-10mg 99%(HPLC) ¥232.00 9 - - -
S80787-50mg 99%(HPLC) ¥496.00 10 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells

產品描述: Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells
靶點: Angiotensin II;RAAS;ProstaglandinReceptor
體內研究: Tranilast (300 mg/kg; administered orally twice a day for 3 days) dose-dependently suppresses angiogenesis in mice
參考文獻: 1. K Ikai , et al. Inhibitory Effect of Tranilast on Prostaglandin D Synthetase. Biochem Pharmacol. 1989 Aug 15;38(16):2673-6. 2. K Miyazawa , et al. Tranilast Antagonizes Angiotensin II and Inhibits Its Biological Effects in Vascular Smooth Muscle Cells. Atherosclerosis. 1996 Apr 5;121(2):167-73. 3. E A Capper, et al. Modulation of Human Monocyte Activities by Tranilast, SB 252218, a Compound Demonstrating Efficacy in Restenosis. J Pharmacol Exp Ther. 2000 Dec;295(3):1061-9. 4. Sara Darakhshan, et al. Tranilast Enhances the Anti-Tumor Effects of Tamoxifen on Human Breast Cancer Cells in Vitro. J Biomed Sci. 2013 Oct 21;20(1):76. 5. M Isaji , et al. Tranilast Inhibits the Proliferation, Chemotaxis and Tube Formation of Human Microvascular Endothelial Cells in Vitro and Angiogenesis in Vivo. Br J Pharmacol. 1997 Nov;122(6):1061-6.
溶解性: DMSO  :  50  mg/mL  (152.75  mM;  Need  ultrasonic)
保存條件: 2-8℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 3.055 ml 15.275 ml 30.55 ml
5 mM 0.611 ml 3.055 ml 6.11 ml
10 mM 0.306 ml 1.528 ml 3.055 ml
50 mM 0.061 ml 0.306 ml 0.611 ml
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

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批號:JS298415 貨號:S20001-25g
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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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