| 產品描述： | Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the treatment of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease |
| 靶點： |
IC50: 13 nM (contractile response of isoprenaline) |
| 體內研究： |
Cyclic somatostatin (5 μg/kg; i.v. per hour once for 18-22 hours) affects visceral metabolism in ruminants |
| 參考文獻： |
1. Murray F, et al. Positive and negative contractile effects of somatostatin-14 on rat ventricular cardiomyocytes. J Cardiovasc Pharmacol. 2001 Mar;37(3):324-32. 2. Bell D, et al. SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes. Cell Physiol Biochem. 2008;22(5-6):653-64. 3. https://pubmed.ncbi.nlm.nih.gov/9374319/ |
| 溶解性： |
H2O : 100 mg/mL (61.05 mM; Need ultrasonic) DMF : 100 mg/mL (61.05 mM; Need ultrasonic) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
0.611 ml |
3.053 ml |
6.105 ml |
| 5 mM |
0.122 ml |
0.611 ml |
1.221 ml |
| 10 mM |
0.061 ml |
0.305 ml |
0.611 ml |
| 50 mM |
0.012 ml |
0.061 ml |
0.122 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京