貨號	規格	價格	上海	北京	武漢	南京
S80661-5mg	97.8%	￥110.00 S80661-5mg ￥110.00 現貨	7 7	-	-	-
S80661-10mg	97.8%	￥190.00 S80661-10mg ￥190.00 現貨	6 6	-	-	-
S80661-25mg	97.8%	￥360.00 S80661-25mg ￥360.00 現貨	6 6	-	-	-
S80661-50mg	97.8%	￥650.00 S80661-50mg ￥650.00 現貨	4 4	-	-	-
S80661-100mg	≥97%	￥1010.00 S80661-100mg ￥1010.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.

產品描述：

PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.

靶點：

PARP:110 nM (IC50);PARP-2:86 nM (IC50);PARP-1:110 nM (IC50);PARP

體內研究：

To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice

參考文獻：

1. Iwashita A, et al. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph 2. Haddad M, et al. Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149(1):23-30. 3. Diani-Moore S, et al. NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7(1):2268.

溶解性：

DMSO : 12.5 mg/mL (37.67 mM; ultrasonic and warming and heat to 60°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.014 ml	15.069 ml	30.139 ml
5 mM	0.603 ml	3.014 ml	6.028 ml
10 mM	0.301 ml	1.507 ml	3.014 ml
50 mM	0.06 ml	0.301 ml	0.603 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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PJ34 HCl